Calcium channel ITPR2 and mitochondria–ER contacts promote cellular senescence and aging

Cellular senescence is induced by stresses and results in a stable proliferation arrest accompanied by a pro-inflammatory secretome. Senescent cells accumulate during aging, promoting various age-related pathologies and limiting lifespan. The endoplasmic reticulum (ER) inositol 1,4,5-trisphosphate r...

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Vydáno v:Nat Commun
Hlavní autoři: Ziegler, Dorian V., Vindrieux, David, Goehrig, Delphine, Jaber, Sara, Collin, Guillaume, Griveau, Audrey, Wiel, Clotilde, Bendridi, Nadia, Djebali, Sophia, Farfariello, Valerio, Prevarskaya, Natacha, Payen, Léa, Marvel, Jacqueline, Aubert, Sébastien, Flaman, Jean-Michel, Rieusset, Jennifer, Martin, Nadine, Bernard, David
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2021
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7851384/
https://ncbi.nlm.nih.gov/pubmed/33526781
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-20993-z
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