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The JAK1/2 inhibitor ruxolitinib delays premature aging phenotypes
Hutchinson–Gilford progeria syndrome (HGPS) is caused by an LMNA mutation that results in the production of the abnormal progerin protein. Children with HGPS display phenotypes of premature aging and have an average lifespan of 13 years. We found earlier that the targeting of the transmembrane prote...
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| Publicado en: | Aging Cell |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
John Wiley and Sons Inc.
2020
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7189991/ https://ncbi.nlm.nih.gov/pubmed/32196928 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.13122 |
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