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The JAK1/2 inhibitor ruxolitinib delays premature aging phenotypes
Hutchinson–Gilford progeria syndrome (HGPS) is caused by an LMNA mutation that results in the production of the abnormal progerin protein. Children with HGPS display phenotypes of premature aging and have an average lifespan of 13 years. We found earlier that the targeting of the transmembrane prote...
Αποθηκεύτηκε σε:
| Τόπος έκδοσης: | Aging Cell |
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| Κύριοι συγγραφείς: | , , , , |
| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
John Wiley and Sons Inc.
2020
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7189991/ https://ncbi.nlm.nih.gov/pubmed/32196928 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.13122 |
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