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The JAK1/2 inhibitor ruxolitinib delays premature aging phenotypes
Hutchinson–Gilford progeria syndrome (HGPS) is caused by an LMNA mutation that results in the production of the abnormal progerin protein. Children with HGPS display phenotypes of premature aging and have an average lifespan of 13 years. We found earlier that the targeting of the transmembrane prote...
Uloženo v:
| Vydáno v: | Aging Cell |
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| Hlavní autoři: | , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
John Wiley and Sons Inc.
2020
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7189991/ https://ncbi.nlm.nih.gov/pubmed/32196928 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.13122 |
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