Targeting ataxia telangiectasia-mutated- and Rad3-related kinase (ATR) in PTEN-deficient breast cancers for personalized therapy

PURPOSE: Phosphate and tensin homolog (PTEN), a negative regulator of PI3K signaling, is involved in DNA repair. ATR is a key sensor of DNA damage and replication stress. We evaluated whether ATR signaling has clinical significance and could be targeted by synthetic lethality in PTEN-deficient tripl...

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Salvato in:
Dettagli Bibliografici
Pubblicato in:Breast Cancer Res Treat
Autori principali: Al-Subhi, Nouf, Ali, Reem, Abdel-Fatah, Tarek, Moseley, Paul M., Chan, Stephen Y. T., Green, Andrew R., Ellis, Ian O., Rakha, Emad A., Madhusudan, Srinivasan
Natura: Artigo
Lingua:Inglês
Pubblicazione: Springer US 2018
Soggetti:
Preclinical Study
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5945733/
https://ncbi.nlm.nih.gov/pubmed/29396668
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10549-018-4683-4
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