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USP49 participates in the DNA damage response by forming a positive feedback loop with p53
The p53 tumor suppressor is a critical factor in the DNA damage response (DDR), and regulation of p53 stability has a key role in this process. In our study, we identified USP49 as a novel deubiquitinase (DUB) for p53 from a library consisting of 80 DUBs and found that USP49 has a positive effect on...
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| Publicado no: | Cell Death Dis |
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| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5945681/ https://ncbi.nlm.nih.gov/pubmed/29748582 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-018-0475-3 |
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