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The regulation of the p53/MDM2 feedback loop by microRNAs
Tumor suppressor p53 and its signaling pathway play a central role in tumor prevention. The E3 ubiquitin ligase MDM2, which is a direct p53 transcriptional target and also the most critical negative regulator of p53, forms an autoregulatory negative feedback loop with p53 in the cell to tightly regu...
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| Published in: | RNA Dis |
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| Main Authors: | , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
2015
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4435570/ https://ncbi.nlm.nih.gov/pubmed/25995995 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.14800/rd.502 |
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