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Down-regulation of p53-inducible microRNAs 192, 194 and 215 impairs the p53/MDM2 auto-regulatory loop in multiple myeloma development
In multiple myeloma (MM), an incurable B-cell neoplasm, mutation or deletion of p53 is rarely detected at diagnosis. Using small-molecule inhibitors of MDM2, we provide evidence that miR-192, 194 and 215, which are down-regulated in a subset of newly diagnosed MMs, can be transcriptionally activated...
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| Auteurs principaux: | , , , , , , , , , , , , , , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2010
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3561766/ https://ncbi.nlm.nih.gov/pubmed/20951946 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2010.09.005 |
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