p53 activates miR-192-5p to mediate vancomycin induced AKI

Pathogenic role of p53 in AKI remains controversial and the underlying mechanism is unclear. Here, we tested whether the inhibition of p53 may ameliorate vancomycin (VAN) induced acute kidney injury (AKI). Mice with p53 knock out (p53-KO) were resistant to VAN induced AKI, indicated by the analysis...

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Bibliographic Details
Published in:Sci Rep
Main Authors: Chen, Jinwen, Wang, Juan, Li, Huiling, Wang, Shixuan, Xiang, Xudong, Zhang, Dongshan
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2016
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5150818/
https://ncbi.nlm.nih.gov/pubmed/27941921
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep38868
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