Genetic heterogeneity and actionable mutations in HER2-positive primary breast cancers and their brain metastases

Brain metastases constitute a challenge in the management of patients with HER2-positive breast cancer treated with anti-HER2 systemic therapies. Here we sought to define the repertoire of mutations private to or enriched for in HER2-positive brain metastases. Massively parallel sequencing targeting...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: De Mattos-Arruda, Leticia, Ng, Charlotte K. Y., Piscuoglio, Salvatore, Gonzalez-Cao, Maria, Lim, Raymond S., De Filippo, Maria R., Fusco, Nicola, Schultheis, Anne M., Ortiz, Carolina, Viteri, Santiago, Arias, Alexandra, Macedo, Gabriel S., Oliveira, Mafalda, Gomez, Patricia, Teixidó, Cristina, Nuciforo, Paolo, Peg, Vicente, Saura, Cristina, Ramon y Cajal, Santiago, Casas, Francesc Tresserra, Weigelt, Britta, Cortes, Javier, Seoane, Joan, Reis-Filho, Jorge S.
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2018
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5945519/
https://ncbi.nlm.nih.gov/pubmed/29755676
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.25041
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