MicroRNA-21 links epithelial-to-mesenchymal transition and inflammatory signals to confer resistance to neoadjuvant trastuzumab and chemotherapy in HER2-positive breast cancer patients

Patients with primary HER2-positive breast cancer benefit from HER2-targeted therapies. Nevertheless, a significant proportion of these patients die of disease progression due to mechanisms of drug resistance. MicroRNAs (miRNAs) are emerging as critical core regulators of drug resistance that act by...

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Veröffentlicht in:Oncotarget
Hauptverfasser: De Mattos-Arruda, Leticia, Bottai, Giulia, Nuciforo, Paolo G., Di Tommaso, Luca, Giovannetti, Elisa, Peg, Vicente, Losurdo, Agnese, Pérez-Garcia, José, Masci, Giovanna, Corsi, Fabio, Cortés, Javier, Seoane, Joan, Calin, George A., Santarpia, Libero
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2015
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4741929/
https://ncbi.nlm.nih.gov/pubmed/26452030
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