Structural and immunologic correlates of chemically stabilized HIV-1 envelope glycoproteins

Inducing broad spectrum neutralizing antibodies against challenging pathogens such as HIV-1 is a major vaccine design goal, but may be hindered by conformational instability within viral envelope glycoproteins (Env). Chemical cross-linking is widely used for vaccine antigen stabilization, but how th...

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Detalhes bibliográficos
Publicado no:PLoS Pathog
Main Authors: Schiffner, Torben, Pallesen, Jesper, Russell, Rebecca A., Dodd, Jonathan, de Val, Natalia, LaBranche, Celia C., Montefiori, David, Tomaras, Georgia D., Shen, Xiaoying, Harris, Scarlett L., Moghaddam, Amin E., Kalyuzhniy, Oleksandr, Sanders, Rogier W., McCoy, Laura E., Moore, John P., Ward, Andrew B., Sattentau, Quentin J.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5944921/
https://ncbi.nlm.nih.gov/pubmed/29746590
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1006986
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