Inhibition of Bcl-2/Bcl-xL and c-MET causes synthetic lethality in model systems of glioblastoma

Recent data suggest that glioblastomas (GBM) activate the c-MET signaling pathway and display increased levels in anti-apoptotic Bcl-2 family members. Therefore, targeting these two deregulated pathways for therapy might yield synergistic treatment responses. We applied extracellular flux analysis t...

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Publicat a:Sci Rep
Autors principals: Zhang, Yiru, Ishida, Chiaki Tsuge, Shu, Chang, Kleiner, Giulio, Sanchez-Quintero, Maria J., Bianchetti, Elena, Quinzii, Catarina M., Westhoff, Mike-Andrew, Karpel-Massler, Georg, Siegelin, Markus D.
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2018
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5943348/
https://ncbi.nlm.nih.gov/pubmed/29743557
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-25802-0
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