miRNA-21 ablation protects against liver injury and necroptosis in cholestasis

Inhibition of microRNA-21 (miR-21) prevents necroptosis in the mouse pancreas. Necroptosis contributes to hepatic necro-inflammation in the common bile duct ligation (BDL) murine model. We aimed to evaluate the role of miR-21 in mediating deleterious processes associated with cholestasis. Mechanisti...

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Vydáno v:Cell Death Differ
Hlavní autoři: Afonso, Marta B., Rodrigues, Pedro M., Simão, André L., Gaspar, Maria M., Carvalho, Tânia, Borralho, Paula, Bañales, Jesús M., Castro, Rui E., Rodrigues, Cecília M. P.
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2017
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5943330/
https://ncbi.nlm.nih.gov/pubmed/29229992
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41418-017-0019-x
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