Inhibition of NF-κB by deoxycholic acid induces miR-21/PDCD4-dependent hepatocellular apoptosis

MicroRNAs (miRNAs/miRs) are key regulators of liver metabolism, while toxic bile acids participate in the development of several liver diseases. We previously demonstrated that deoxycholic acid (DCA), a cytotoxic bile acid implicated in the pathogenesis of non-alcoholic fatty liver disease, inhibits...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Rodrigues, Pedro M., Afonso, Marta B., Simão, André L., Borralho, Pedro M., Rodrigues, Cecília M. P., Castro, Rui E.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4664913/
https://ncbi.nlm.nih.gov/pubmed/26621219
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep17528
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