Impact of UGT1A1 polymorphisms on Raltegravir and its glucuronide plasma concentrations in a cohort of HIV-1 infected patients

The aim of this study was to evaluate the effect of UGT1A1 polymorphisms on Raltegravir (RAL) and its metabolite RAL-glucuronide trough plasma concentrations ([RAL]plasma and [RAL-glu]plasma) and on the metabolic ratio (MR): [RAL-glu]plasma/[RAL]plasma. UGT1A1 genotyping was performed on 96 patients...

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Udgivet i:Sci Rep
Main Authors: Belkhir, Leïla, Seguin-Devaux, Carole, Elens, Laure, Pauly, Caroline, Gengler, Nicolas, Schneider, Serge, Ruelle, Jean, Haufroid, Vincent, Vandercam, Bernard
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5943329/
https://ncbi.nlm.nih.gov/pubmed/29743555
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-25803-z
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