Lentiviral infection of proliferating brain macrophages in HIV and simian immunodeficiency virus encephalitis despite sterile alpha motif and histidine-aspartate domain-containing protein 1 expression

OBJECTIVE: HIV-1 infection of the brain and related cognitive impairment remain prevalent in HIV-1-infected individuals despite combination antiretroviral therapy. Sterile alpha motif and histidine-aspartate domain-containing protein 1 (SAMHD1) is a newly identified host restriction factor that bloc...

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Detalhes bibliográficos
Publicado no:AIDS
Main Authors: Lindgren, Allison A., Filipowicz, Adam R., Hattler, Julian B., Kim, Soon Ok, Chung, Hye Kyung, Kuroda, Marcelo J., Johnson, Edward M., Kim, Woong-Ki
Formato: Artigo
Idioma:Inglês
Publicado em: Lippincott Williams & Wilkins 2018
Assuntos:
Basic Science
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5943146/
https://ncbi.nlm.nih.gov/pubmed/29698322
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/QAD.0000000000001793
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