Complement C5 but not C3 is expendable for tissue factor activation by cofactor-independent antiphospholipid antibodies

The complement and coagulation cascades interact at multiple levels in thrombosis and inflammatory diseases. In venous thrombosis, complement factor 3 (C3) is crucial for platelet and tissue factor (TF) procoagulant activation dependent on protein disulfide isomerase (PDI). Furthermore, C5 selective...

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Detalhes bibliográficos
Publicado no:Blood Adv
Main Authors: Müller-Calleja, Nadine, Ritter, Svenja, Hollerbach, Anne, Falter, Tanja, Lackner, Karl J., Ruf, Wolfram
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2018
Assuntos:
Thrombosis and Hemostasis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5942002/
https://ncbi.nlm.nih.gov/pubmed/29716893
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2018017095
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