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Unpicking allosteric mechanisms of homo-oligomeric proteins by determining their successive ligand binding constants
Advances in native mass spectrometry and single-molecule techniques have made it possible in recent years to determine the values of successive ligand binding constants for large multi-subunit proteins. Given these values, it is possible to distinguish between different allosteric mechanisms and, th...
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| Publicado no: | Philos Trans R Soc Lond B Biol Sci |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Royal Society
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5941171/ https://ncbi.nlm.nih.gov/pubmed/29735730 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1098/rstb.2017.0176 |
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