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Sequential allosteric mechanism of ATP hydrolysis by the CCT/TRiC chaperone is revealed through Arrhenius analysis

Knowing the mechanism of allosteric switching is important for understanding how molecular machines work. The CCT/TRiC chaperonin nanomachine undergoes ATP-driven conformational changes that are crucial for its folding function. Here, we demonstrate that insight into its allosteric mechanism of ATP...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Gruber, Ranit, Levitt, Michael, Horovitz, Amnon
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2017
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5441784/
https://ncbi.nlm.nih.gov/pubmed/28461478
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1617746114
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