Recurrent hotspot mutations in HRAS Q61 and PI3K-AKT pathway genes as drivers of breast adenomyoepitheliomas

Adenomyoepithelioma of the breast is a rare tumor characterized by epithelial−myoepithelial differentiation, whose genetic underpinning is largely unknown. Here we show through whole-exome and targeted massively parallel sequencing analysis that whilst estrogen receptor (ER)-positive adenomyoepithel...

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Publicat a:Nat Commun
Autors principals: Geyer, Felipe C., Li, Anqi, Papanastasiou, Anastasios D., Smith, Alison, Selenica, Pier, Burke, Kathleen A., Edelweiss, Marcia, Wen, Huei-Chi, Piscuoglio, Salvatore, Schultheis, Anne M., Martelotto, Luciano G., Pareja, Fresia, Kumar, Rahul, Brandes, Alissa, Fan, Dan, Basili, Thais, Da Cruz Paula, Arnaud, Lozada, John R., Blecua, Pedro, Muenst, Simone, Jungbluth, Achim A., Foschini, Maria P., Wen, Hannah Y., Brogi, Edi, Palazzo, Juan, Rubin, Brian P., Ng, Charlotte K. Y., Norton, Larry, Varga, Zsuzsanna, Ellis, Ian O., Rakha, Emad A., Chandarlapaty, Sarat, Weigelt, Britta, Reis-Filho, Jorge S.
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2018
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5940840/
https://ncbi.nlm.nih.gov/pubmed/29739933
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-04128-5
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