Immunohistochemical Assessment of HRAS Q61R Mutations in Breast Adenomyoepitheliomas

AIMS: Breast adenomyoepitheliomas (AMEs) are uncommon tumors. Most estrogen receptor (ER)-positive AMEs have mutations in PI3K pathway genes, whereas ER-negative AMEs usually harbor concurrent mutations affecting the HRAS Q61 hotspot and PI3K pathway genes. Here, we sought to determine the sensitivi...

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Gepubliceerd in:Histopathology
Hoofdauteurs: Pareja, Fresia, Toss, Michael S., Geyer, Felipe C, da Silva, Edaise M., Vahdatinia, Mahsa, Sebastiao, Ana Paula Martins, Selenica, Pier, Szatrowski, Austin, Edelweiss, Marcia, Wen, Hannah Y., Mihai, Raluca, Varga, Zsuzsanna, Foschini, Maria P., Rubin, Brian P, Ellis, Ian O., Chandarlapaty, Sarat, Jungbluth, Achim A., Brogi, Edi, Weigelt, Britta, Reis-Filho, Jorge S., Rakha, Emad A.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2020
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7225035/
https://ncbi.nlm.nih.gov/pubmed/31887226
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/his.14057
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