Matrilysin/MMP-7 Cleavage of Perlecan/HSPG2 Complexed with Semaphorin 3A Supports FAK-Mediated Stromal Invasion by Prostate Cancer Cells

Interrupting the interplay between cancer cells and extracellular matrix (ECM) is a strategy to halt tumor progression and stromal invasion. Perlecan/heparan sulfate proteoglycan 2 (HSPG2) is an extracellular proteoglycan that orchestrates tumor angiogenesis, proliferation, differentiation and invas...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Grindel, Brian J., Martinez, Jerahme R., Tellman, Tristen V., Harrington, Daniel A., Zafar, Hamim, Nakhleh, Luay, Chung, Leland W., Farach-Carson, Mary C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5940808/
https://ncbi.nlm.nih.gov/pubmed/29740048
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-25435-3
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