Use of LC-MS/MS to Identify Matrilysin/Matrix Metalloproteinase-7(MMP7) Cleavage Products of Perlecan (PLN)/Heparan Sulfate Proteoglycan (HSPG2)

Introduction: PLN/HSPG2, a 450 KDa heparan sulfate (HS) proteoglycan, is expressed in the basement membrane (BM) underlying epithelial and endothelial cells. Break down of PLN and other BM proteins is thought to play a critical role in prostate cancer (PCa) metastasis. During PCa metastasis, a varie...

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Bibliographic Details
Main Authors: Grindel, B.J., Chung, L.W., Farach-Carson, M.C., Pennington, Christopher
Format: Artigo
Language:Inglês
Published: Association of Biomolecular Resource Facilities 2013
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Poster Session Abstracts
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3635252/
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