Pharmacologic inhibition of STAT5 in acute myeloid leukemia

The transcription factor STAT5 is an essential downstream mediator of many tyrosine kinases (TKs), particularly in hematopoietic cancers. STAT5 is activated by FLT3-ITD, which is a constitutively active TK driving the pathogenesis of acute myeloid leukemia (AML). Since STAT5 is a critical mediator o...

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Pubblicato in:Leukemia
Autori principali: Wingelhofer, Bettina, Maurer, Barbara, Heyes, Elizabeth C., Cumaraswamy, Abbarna A., Berger-Becvar, Angelika, de Araujo, Elvin D., Orlova, Anna, Freund, Patricia, Ruge, Frank, Park, Jisung, Tin, Gary, Ahmar, Siawash, Lardeau, Charles-Hugues, Sadovnik, Irina, Bajusz, Dávid, Keserű, György Miklós, Grebien, Florian, Kubicek, Stefan, Valent, Peter, Gunning, Patrick T., Moriggl, Richard
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5940656/
https://ncbi.nlm.nih.gov/pubmed/29472718
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41375-017-0005-9
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