Pharmacologic inhibition of STAT5 in acute myeloid leukemia

The transcription factor STAT5 is an essential downstream mediator of many tyrosine kinases (TKs), particularly in hematopoietic cancers. STAT5 is activated by FLT3-ITD, which is a constitutively active TK driving the pathogenesis of acute myeloid leukemia (AML). Since STAT5 is a critical mediator o...

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Xehetasun bibliografikoak
Argitaratua izan da:Leukemia
Egile Nagusiak: Wingelhofer, Bettina, Maurer, Barbara, Heyes, Elizabeth C., Cumaraswamy, Abbarna A., Berger-Becvar, Angelika, de Araujo, Elvin D., Orlova, Anna, Freund, Patricia, Ruge, Frank, Park, Jisung, Tin, Gary, Ahmar, Siawash, Lardeau, Charles-Hugues, Sadovnik, Irina, Bajusz, Dávid, Keserű, György Miklós, Grebien, Florian, Kubicek, Stefan, Valent, Peter, Gunning, Patrick T., Moriggl, Richard
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Nature Publishing Group UK 2018
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5940656/
https://ncbi.nlm.nih.gov/pubmed/29472718
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41375-017-0005-9
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