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Brain mitochondrial iron accumulates in Huntington’s disease, mediates mitochondrial dysfunction, and can be removed pharmacologically

Mitochondrial bioenergetic dysfunction is involved in neurodegeneration in Huntington’s disease (HD). Iron is critical for normal mitochondrial bioenergetics but can also contribute to pathogenic oxidation. The accumulation of iron in the brain occurs in mouse models and in human HD. Yet the role of...

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Pubblicato in:Free Radic Biol Med
Autori principali: Agrawal, Sonal, Fox, Julia, Thyagarajan, Baskaran, Fox, Jonathan
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2018
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5940499/
https://ncbi.nlm.nih.gov/pubmed/29625173
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2018.04.002
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