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Autophagy balances mtDNA synthesis and degradation by DNA polymerase POLG during starvation
Mitochondria contain tens to thousands of copies of their own genome (mitochondrial DNA [mtDNA]), creating genetic redundancy capable of buffering mutations in mitochondrial genes essential for cellular function. However, the mechanisms regulating mtDNA copy number have been elusive. Here we found t...
Gardado en:
| Publicado en: | J Cell Biol |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Rockefeller University Press
2018
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5940314/ https://ncbi.nlm.nih.gov/pubmed/29519802 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201801168 |
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