Basal mitophagy is widespread in Drosophila but minimally affected by loss of Pink1 or parkin

The Parkinson’s disease factors PINK1 and parkin are strongly implicated in stress-induced mitophagy in vitro, but little is known about their impact on basal mitophagy in vivo. We generated transgenic Drosophila melanogaster expressing fluorescent mitophagy reporters to evaluate the impact of Pink1...

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Vydáno v:J Cell Biol
Hlavní autoři: Lee, Juliette J., Sanchez-Martinez, Alvaro, Zarate, Aitor Martinez, Benincá, Cristiane, Mayor, Ugo, Clague, Michael J., Whitworth, Alexander J.
Médium: Artigo
Jazyk:Inglês
Vydáno: Rockefeller University Press 2018
Témata:
Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5940313/
https://ncbi.nlm.nih.gov/pubmed/29500189
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201801044
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