Basal mitophagy is widespread in Drosophila but minimally affected by loss of Pink1 or parkin

The Parkinson’s disease factors PINK1 and parkin are strongly implicated in stress-induced mitophagy in vitro, but little is known about their impact on basal mitophagy in vivo. We generated transgenic Drosophila melanogaster expressing fluorescent mitophagy reporters to evaluate the impact of Pink1...

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Detalles Bibliográficos
Publicado en:J Cell Biol
Main Authors: Lee, Juliette J., Sanchez-Martinez, Alvaro, Zarate, Aitor Martinez, Benincá, Cristiane, Mayor, Ugo, Clague, Michael J., Whitworth, Alexander J.
Formato: Artigo
Idioma:Inglês
Publicado: Rockefeller University Press 2018
Assuntos:
Research Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5940313/
https://ncbi.nlm.nih.gov/pubmed/29500189
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201801044
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