Basal mitophagy is widespread in Drosophila but minimally affected by loss of Pink1 or parkin

The Parkinson’s disease factors PINK1 and parkin are strongly implicated in stress-induced mitophagy in vitro, but little is known about their impact on basal mitophagy in vivo. We generated transgenic Drosophila melanogaster expressing fluorescent mitophagy reporters to evaluate the impact of Pink1...

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Publicat a:J Cell Biol
Autors principals: Lee, Juliette J., Sanchez-Martinez, Alvaro, Zarate, Aitor Martinez, Benincá, Cristiane, Mayor, Ugo, Clague, Michael J., Whitworth, Alexander J.
Format: Artigo
Idioma:Inglês
Publicat: Rockefeller University Press 2018
Matèries:
Research Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5940313/
https://ncbi.nlm.nih.gov/pubmed/29500189
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201801044
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