Combination anti-Aβ treatment maximizes cognitive recovery and rebalances mTOR signaling in APP mice

Drug development for Alzheimer’s disease has endeavored to lower amyloid β (Aβ) by either blocking production or promoting clearance. The benefit of combining these approaches has been examined in mouse models and shown to improve pathological measures of disease over single treatment; however, the...

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Detalhes bibliográficos
Publicado no:J Exp Med
Main Authors: Chiang, Angie C.A., Fowler, Stephanie W., Savjani, Ricky R., Hilsenbeck, Susan G., Wallace, Clare E., Cirrito, John R., Das, Pritam, Jankowsky, Joanna L.
Formato: Artigo
Idioma:Inglês
Publicado em: Rockefeller University Press 2018
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5940263/
https://ncbi.nlm.nih.gov/pubmed/29626114
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20171484
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