Genetic Suppression of Transgenic APP Rescues Hypersynchronous Network Activity in a Mouse Model of Alzeimer's Disease

Alzheimer's disease (AD) is associated with an elevated risk for seizures that may be fundamentally connected to cognitive dysfunction. Supporting this link, many mouse models for AD exhibit abnormal electroencephalogram (EEG) activity in addition to the expected neuropathology and cognitive de...

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Detalhes bibliográficos
Main Authors: Born, Heather A., Kim, Ji-Yoen, Savjani, Ricky R., Das, Pritam, Dabaghian, Yuri A., Guo, Qinxi, Yoo, Jong W., Schuler, Dorothy R., Cirrito, John R., Zheng, Hui, Golde, Todd E., Noebels, Jeffrey L., Jankowsky, Joanna L.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2014
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3951689/
https://ncbi.nlm.nih.gov/pubmed/24623762
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.5171-13.2014
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