Transgenic APP expression during postnatal development causes persistent locomotor hyperactivity in the adult

BACKGROUND: Transgenic mice expressing disease-associated proteins have become standard tools for studying human neurological disorders. Transgenes are often expressed using promoters chosen to drive continuous high-level expression throughout life rather than temporal and spatial fidelity to the en...

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Bibliographic Details
Main Authors: Rodgers, Shaefali P, Born, Heather A, Das, Pritam, Jankowsky, Joanna L
Format: Artigo
Language:Inglês
Published: BioMed Central 2012
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3457908/
https://ncbi.nlm.nih.gov/pubmed/22709352
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1750-1326-7-28
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