Genetic Modulation of Soluble Aβ Rescues Cognitive and Synaptic Impairment in a Mouse Model of Alzheimer's Disease

An unresolved debate in Alzheimer's disease (AD) is whether amyloid plaques are pathogenic, causing overt physical disruption of neural circuits, or protective, sequestering soluble forms of amyloid-β (Aβ) that initiate synaptic damage and cognitive decline. Few animal models of AD have been ca...

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Detalhes bibliográficos
Main Authors: Fowler, Stephanie W., Chiang, Angie C. A., Savjani, Ricky R., Larson, Megan E., Sherman, Mathew A., Schuler, Dorothy R., Cirrito, John R., Lesné, Sylvain E., Jankowsky, Joanna L.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2014
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4044248/
https://ncbi.nlm.nih.gov/pubmed/24899710
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0572-14.2014
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