Dysregulation of sphingolipid metabolism contributes to bortezomib-induced neuropathic pain

The development of chemotherapy-induced painful peripheral neuropathy is a major dose-limiting side effect of many chemotherapeutics, including bortezomib, but the mechanisms remain poorly understood. We now report that bortezomib causes the dysregulation of de novo sphingolipid metabolism in the sp...

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Detalhes bibliográficos
Publicado no:J Exp Med
Main Authors: Stockstill, Katherine, Doyle, Timothy M., Yan, Xisheng, Chen, Zhoumou, Janes, Kali, Little, Joshua W., Braden, Kathryn, Lauro, Filomena, Giancotti, Luigino Antonio, Harada, Caron Mitsue, Yadav, Ruchi, Xiao, Wen Hua, Lionberger, Jack M., Neumann, William L., Bennett, Gary J., Weng, Han-Rong, Spiegel, Sarah, Salvemini, Daniela
Formato: Artigo
Idioma:Inglês
Publicado em: Rockefeller University Press 2018
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5940258/
https://ncbi.nlm.nih.gov/pubmed/29703731
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20170584
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