Dysregulation of sphingolipid metabolism contributes to bortezomib-induced neuropathic pain

The development of chemotherapy-induced painful peripheral neuropathy is a major dose-limiting side effect of many chemotherapeutics, including bortezomib, but the mechanisms remain poorly understood. We now report that bortezomib causes the dysregulation of de novo sphingolipid metabolism in the sp...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:J Exp Med
Egile Nagusiak: Stockstill, Katherine, Doyle, Timothy M., Yan, Xisheng, Chen, Zhoumou, Janes, Kali, Little, Joshua W., Braden, Kathryn, Lauro, Filomena, Giancotti, Luigino Antonio, Harada, Caron Mitsue, Yadav, Ruchi, Xiao, Wen Hua, Lionberger, Jack M., Neumann, William L., Bennett, Gary J., Weng, Han-Rong, Spiegel, Sarah, Salvemini, Daniela
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Rockefeller University Press 2018
Gaiak:
Research Articles
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5940258/
https://ncbi.nlm.nih.gov/pubmed/29703731
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20170584
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