Dysregulation of sphingolipid metabolism contributes to bortezomib-induced neuropathic pain

The development of chemotherapy-induced painful peripheral neuropathy is a major dose-limiting side effect of many chemotherapeutics, including bortezomib, but the mechanisms remain poorly understood. We now report that bortezomib causes the dysregulation of de novo sphingolipid metabolism in the sp...

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Pubblicato in:J Exp Med
Autori principali: Stockstill, Katherine, Doyle, Timothy M., Yan, Xisheng, Chen, Zhoumou, Janes, Kali, Little, Joshua W., Braden, Kathryn, Lauro, Filomena, Giancotti, Luigino Antonio, Harada, Caron Mitsue, Yadav, Ruchi, Xiao, Wen Hua, Lionberger, Jack M., Neumann, William L., Bennett, Gary J., Weng, Han-Rong, Spiegel, Sarah, Salvemini, Daniela
Natura: Artigo
Lingua:Inglês
Pubblicazione: Rockefeller University Press 2018
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Research Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5940258/
https://ncbi.nlm.nih.gov/pubmed/29703731
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20170584
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