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Stereoselective Synthesis of 3,3′-Bisindolines by Organocatalytic Michael Additions of Fluorooxindole Enolates to Isatylidene Malononitriles in Aqueous Solution

A highly diastereoselective organocatalytic reaction for the synthesis of fluorinated 3,3′-bisindolines exhibiting adjacent tetrasubstituted carbon stereocenters is described. A broad variety of heterochiral bisindolines was prepared in 91-99% yield using 3-fluorooxindoles and isatylidene malononitr...

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Detalhes bibliográficos
Publicado no:Adv Synth Catal
Main Authors: Balaraman, Kaluvu, Ding, Ransheng, Wolf, Christian
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5939588/
https://ncbi.nlm.nih.gov/pubmed/29755308
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/adsc.201701107
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