SMPD3 deficiency perturbs neuronal proteostasis and causes progressive cognitive impairment

Neutral sphingomyelinase smpd3 is most abundantly expressed in neurons of brain. The function of SMPD3 has remained elusive. Here, we report a pathogenetic nexus between absence of SMPD3 in the Golgi compartment (GC) of neurons of the smpd3-/- mouse brain, inhibition of Golgi vesicular protein trans...

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Bibliographic Details
Published in:Cell Death Dis
Main Authors: Stoffel, Wilhelm, Jenke, Britta, Schmidt-Soltau, Inga, Binczek, Erika, Brodesser, Susanne, Hammels, Ina
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2018
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5938706/
https://ncbi.nlm.nih.gov/pubmed/29725009
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-018-0560-7
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