Neutral sphingomyelinase (SMPD3) deficiency disrupts the Golgi secretory pathway and causes growth inhibition

Systemic loss of neutral sphingomyelinase (SMPD3) in mice leads to a novel form of systemic, juvenile hypoplasia (dwarfism). SMPD3 deficiency in mainly two growth regulating cell types contributes to the phenotype, in chondrocytes of skeletal growth zones to skeletal malformation and chondrodysplasi...

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Publicado no:Cell Death Dis
Main Authors: Stoffel, Wilhelm, Hammels, Ina, Jenke, Bitta, Binczek, Erika, Schmidt-Soltau, Inga, Brodesser, Susanne, Schauss, Astrid, Etich, Julia, Heilig, Juliane, Zaucke, Frank
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5260872/
https://ncbi.nlm.nih.gov/pubmed/27882938
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2016.385
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