SMPD3 deficiency perturbs neuronal proteostasis and causes progressive cognitive impairment

Neutral sphingomyelinase smpd3 is most abundantly expressed in neurons of brain. The function of SMPD3 has remained elusive. Here, we report a pathogenetic nexus between absence of SMPD3 in the Golgi compartment (GC) of neurons of the smpd3-/- mouse brain, inhibition of Golgi vesicular protein trans...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Cell Death Dis
Main Authors: Stoffel, Wilhelm, Jenke, Britta, Schmidt-Soltau, Inga, Binczek, Erika, Brodesser, Susanne, Hammels, Ina
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5938706/
https://ncbi.nlm.nih.gov/pubmed/29725009
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-018-0560-7
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados