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SMPD3 deficiency perturbs neuronal proteostasis and causes progressive cognitive impairment
Neutral sphingomyelinase smpd3 is most abundantly expressed in neurons of brain. The function of SMPD3 has remained elusive. Here, we report a pathogenetic nexus between absence of SMPD3 in the Golgi compartment (GC) of neurons of the smpd3-/- mouse brain, inhibition of Golgi vesicular protein trans...
Gespeichert in:
| Veröffentlicht in: | Cell Death Dis |
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| Hauptverfasser: | , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Nature Publishing Group UK
2018
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5938706/ https://ncbi.nlm.nih.gov/pubmed/29725009 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-018-0560-7 |
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