Grainyhead-like 2 (GRHL2) knockout abolishes oral cancer development through reciprocal regulation of the MAP kinase and TGF-β signaling pathways

Grainyhead-Like 2 (GRHL2) is an epithelial-specific transcription factor that regulates epithelial morphogenesis and differentiation. Prior studies suggested inverse regulation between GRHL2 and TGF-β in epithelial plasticity and potential carcinogenesis. Here, we report the role of GRHL2 in oral ca...

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Bibliografske podrobnosti
izdano v:Oncogenesis
Main Authors: Chen, Wei, Kang, Kyung L., Alshaikh, Abdullah, Varma, Saaket, Lin, Yi-Ling, Shin, Ki-Hyuk, Kim, Reuben, Wang, Cun-Yu, Park, No-Hee, Walentin, Katharina, Schmidt-Ott, Kai M., Kang, Mo K.
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2018
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5938237/
https://ncbi.nlm.nih.gov/pubmed/29735981
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41389-018-0047-5
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