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The p63 Gene Is Regulated by Grainyhead-like 2 (GRHL2) through Reciprocal Feedback and Determines the Epithelial Phenotype in Human Keratinocytes

In this study, we investigated the effects of p63 modulation in epithelial plasticity in human keratinocytes. The p63 isoforms ΔNp63α, ΔNp63β, and ΔNp63γ were ectopically expressed in normal human epidermal keratinocytes (NHEKs). The epithelial or mesenchymal state was determined by morphological ch...

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Dades bibliogràfiques
Publicat a:J Biol Chem
Autors principals: Mehrazarin, Shebli, Chen, Wei, Oh, Ju-Eun, Liu, Zi X., Kang, Kyung L., Yi, Jin K., Kim, Reuben H., Shin, Ki-Hyuk, Park, No-Hee, Kang, Mo K.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2015
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4528158/
https://ncbi.nlm.nih.gov/pubmed/26085095
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.659144
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