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Bmi-1 extends the lifespan of normal human oral keratinocytes by inhibiting the TGF-β signaling
We previously demonstrated that Bmi-1 extended the in vitro life span of normal human oral keratinocytes (NHOK). We now report that the prolonged life span of NHOK by Bmi-1 is, in part, due to inhibition of the TGF-β signaling pathway. Serial subculture of NHOK resulted in replicative senescence and...
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| Autori principali: | , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2010
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2924923/ https://ncbi.nlm.nih.gov/pubmed/20630502 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yexcr.2010.04.013 |
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