Bmi-1 extends the lifespan of normal human oral keratinocytes by inhibiting the TGF-β signaling

We previously demonstrated that Bmi-1 extended the in vitro life span of normal human oral keratinocytes (NHOK). We now report that the prolonged life span of NHOK by Bmi-1 is, in part, due to inhibition of the TGF-β signaling pathway. Serial subculture of NHOK resulted in replicative senescence and...

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Detalhes bibliográficos
Main Authors: Kim, Reuben H., Lieberman, Mark B., Lee, Rachel, Shin, Ki-Hyuk, Mehrazarin, Shebli, Oh, Ju-Eun, Park, No-Hee, Kang, Mo K.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2924923/
https://ncbi.nlm.nih.gov/pubmed/20630502
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yexcr.2010.04.013
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