Sulfur mustard induced mast cell degranulation in mouse skin is inhibited by a novel anti-inflammatory and anticholinergic bifunctional prodrug

Sulfur mustard (SM, bis(2-chloroethyl sulfide) is a potent vesicating agent known to cause skin inflammation, necrosis and blistering. Evidence suggests that inflammatory cells and mediators that they generate are important in the pathogenic responses to SM. In the present studies we investigated th...

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Pubblicato in:Toxicol Lett
Autori principali: Joseph, Laurie B., Composto, Gabriella M., Perez, Roberto M., Kim, Hong-Duck, Casillas, Robert P., Heindel, Ned D., Young, Sherri C., Lacey, Carl J., Saxena, Jaya, Guillon, Christophe D., Croutch, Claire R., Laskin, Jeffrey D., Heck, Diane E.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5938161/
https://ncbi.nlm.nih.gov/pubmed/29127031
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.toxlet.2017.11.005
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