Functional Genome-wide Screen Identifies Pathways Restricting Central Nervous System Axonal Regeneration

Axonal regrowth is crucial for recovery from CNS injury but is severely restricted in adult mammals. We used a genome-wide loss-of-function screen for factors limiting axonal regeneration from cerebral cortical neurons in vitro. Knockdown of 16,007 individual genes identified 580 significant phenoty...

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Udgivet i:Cell Rep
Main Authors: Sekine, Yuichi, Lin-Moore, Alexander, Chenette, Devon M., Wang, Xingxing, Jiang, Zhaoxin, Cafferty, William B., Hammarlund, Marc, Strittmatter, Stephen M.
Format: Artigo
Sprog:Inglês
Udgivet: 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5937716/
https://ncbi.nlm.nih.gov/pubmed/29642001
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2018.03.058
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