Inhibition of Poly-ADP-Ribosylation Fails to Increase Axonal Regeneration or Improve Functional Recovery after Adult Mammalian CNS Injury

After traumatic damage of the brain or spinal cord, many surviving neurons are disconnected, and recovery of function is limited by poor axon regeneration. Recent data have suggested that poly ADP-ribosylation plays a role in limiting axonal regrowth such that inhibition of poly (ADP-ribose) polymer...

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Bibliographic Details
Published in:eNeuro
Main Authors: Wang, Xingxing, Sekine, Yuichi, Byrne, Alexandra B., Cafferty, William B.J., Hammarlund, Marc, Strittmatter, Stephen M.
Format: Artigo
Language:Inglês
Published: Society for Neuroscience 2016
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Negative Results
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5187389/
https://ncbi.nlm.nih.gov/pubmed/28032120
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/ENEURO.0270-16.2016
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