Substituents at the C3′ and C3′N positions are critical for taxanes to overcome acquired resistance of cancer cells to paclitaxel

We tested the role of substituents at the C3′ and C3′N positions of the taxane molecule to identify taxane derivatives capable of overcoming acquired resistance to paclitaxel. Paclitaxel-resistant sublines SK-BR-3/PacR and MCF-7/PacR as well as the original paclitaxel-sensitive breast cancer cell li...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Toxicol Appl Pharmacol
Päätekijät: Jelínek, Michael, Balušíková, Kamila, Daniel, Petr, Němcová-Fürstová, Vlasta, Kirubakaran, Palani, Jaček, Martin, Wei, Longfei, Wang, Xin, Vondrášek, Jiří, Ojima, Iwao, Kovář, Jan
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2018
Aiheet:
Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5937276/
https://ncbi.nlm.nih.gov/pubmed/29625142
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.taap.2018.04.002
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