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p38 MAPK Is Activated but Does Not Play a Key Role during Apoptosis Induction by Saturated Fatty Acid in Human Pancreatic β-Cells

Saturated stearic acid (SA) induces apoptosis in the human pancreatic β-cells NES2Y. However, the molecular mechanisms involved are unclear. We showed that apoptosis-inducing concentrations of SA activate the p38 MAPK signaling pathway in these cells. Therefore, we tested the role of p38 MAPK signal...

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Detalhes bibliográficos
Publicado no:Int J Mol Sci
Main Authors: Šrámek, Jan, Němcová-Fürstová, Vlasta, Balušíková, Kamila, Daniel, Petr, Jelínek, Michael, James, Roger F., Kovář, Jan
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2016
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4783893/
https://ncbi.nlm.nih.gov/pubmed/26861294
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms17020159
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