Caspase-2 is involved in cell death induction by taxanes in breast cancer cells

BACKGROUND: We studied the role of caspase-2 in apoptosis induction by taxanes (paclitaxel, novel taxane SB-T-1216) in breast cancer cells using SK-BR-3 (nonfunctional p53, functional caspase-3) and MCF-7 (functional p53, nonfunctional caspase-3) cell lines. RESULTS: Both taxanes induced apoptosis i...

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Hauptverfasser: Jelínek, Michael, Balušíková, Kamila, Kopperová, Dana, Němcová-Fürstová, Vlasta, Šrámek, Jan, Fidlerová, Julie, Zanardi, Ilaria, Ojima, Iwao, Kovář, Jan
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2013
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Primary Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3685568/
https://ncbi.nlm.nih.gov/pubmed/23672670
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1475-2867-13-42
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